|About the Book|
Progress in Myeloma is a collection of recent papers dealing with clinical and experimental plasma cell tumors. This body of work may soon provide a particularly advantageous basis for defining in biochemical and genetic terms the nature of criticalMoreProgress in Myeloma is a collection of recent papers dealing with clinical and experimental plasma cell tumors. This body of work may soon provide a particularly advantageous basis for defining in biochemical and genetic terms the nature of critical alterations in the neoplastic transformation of immunoglobulin producing cells. It hardly needs mention that such information should be invaluable for the design of new therapeutic approaches.This book comprises 14 chapters, with the first focusing on the epidemiology of multiple myeloma and related plasma cell disorders. Succeeding chapters discuss in vitro bone resorption by human myeloma cells- plasma cell myeloma and Waldenstroms macroglobulinemia in black and white South Africans- in vivo pulse labeling studies of murine LPC-1 plasmacytoma using 6-14C-arginine- and myelomas as models to study activation and suppression of normal lymphocytes. Other chapters cover regulation of murine myeloma cell growth and differentiation- characteristics of multiple myeloma as an immunodeficiency disease- immunodeficiency induced by plasma cell tumors- myeloma growth kinetics- the extent of clonai involvement in multiple myeloma- regulation of the growth of myeloma tumor cells- non-random chromosome changes- a review of therapeutic trials in multiple myeloma and perspectives for future trails- and genetic considerations in plasmacytomas of BALB/c, NZB, and (BALB/c X NZB) F1 mice.This book will be of interest to practitioners in the fields of genetics, biochemistry, and biology.